Taken together, our findings highlight a large number of potential novel interactors with intermediate filaments and are in line with the hypothesis that the binding to vimentin of ECM and cell migration proteins, as well as of the proteins of RNA metabolism and function, such as the protein SON, allows the function of molecular pathways at the time and space required for dynamic changes of cells, such as during EMT and cancer metastasis. Here, VIM is linked to cancer.