3.10. Ectopic Expression of J-PKAc in Hepatoblastoma Cell Lines HepG2 and Huh6 Enhances ph-S675-β-Catenin and HDAC1-Sp5 Pathways, Leading to Alterations Like Those Observed in Fusion-Positive HBLs/HCN-NOSs. The gene discussed is HDAC1; the disease is hepatoblastoma.