SPP2 and neoplasm: Among other downregulated tumor suppressors, we found CNTFR, which inhibits tumor growth in xenograft models [22]; Orphan Nuclear Receptor (NROB2), which suppresses tumorigenesis in mouse models by modulating the expression of cyclin D1 [23]; TRIM15, which inhibits tumor cell invasion [24]; Decorin (DCN), which displays anti-tumor activities in breast cancer [25]; Alcohol Dehydrogenases 1c and 4, which inhibit growth, migration, invasion, and colony formation in CRC cancer [26]; and secreted phosphoprotein 2 (SPP2), which inhibits liver regeneration [27].