Inhibiting FGFR4 by BLU9931 will inhibit the activation of GSK3β/β-catenin in Forkhead box C1 (FOXC1) FOXC1-overexpressed metastatic CRC colonization, which suggests an interaction between FGF and Wnt signaling to regulate metastasis, especially when FOXC1 is strongly associated with metastasis in CRC [88]. The gene discussed is FOXC1; the disease is colorectal carcinoma.