Additionally, we identify miR-217-5p as an EZH2 regulator in GBM cells and show that miR-217-5p reconstitution using advanced nanoparticle formulations re-activates the PRC2-repressed genes, inhibits GSC formation, impairs tumor growth, and enhances the effects of ionizing radiation in an orthotopic model of GBM. The gene discussed is EZH2; the disease is neoplasm.