qRT-PCR analysis confirmed that 7 of these 15 genes (CAMK2B, EGR3, NPAS2, PCDH8, RGS6, SOX1, and TESC) were consistently downregulated by Oct4/Sox2 across two distinct patient-derived GBM neurosphere models (Figure 2C). The gene discussed is SOX1; the disease is glioblastoma.