EZH2 and neoplasm: The subsequent experiments focused on miR-217-5p since (i) both EZH2 and H3K27me3 were more robustly induced following miR-217-5p inhibition compared to miR-124-3p inhibition, and (ii) a role for miR-124-3p (i.e., a tumor suppressor function) has been previously described in GBM [31].