In this section, we review current knowledge about the expression profiles and roles of VEGF, Ang-2, MMP-9, FGF-2, TNF-α, CXCL-12, CXCL-2, NGAL, IGF-1, progranulin, and angiogenin in CLL (Table 1). The gene discussed is GRN; the disease is B-cell chronic lymphocytic leukemia.