Furthermore, advanced CLL is associated with elevated plasma/serum concentrations of VEGF, Ang-2, and MMP-9 (expressed by circulating blood CLL cells) [57,64,65,77,78,79,80,81] (Table 1), and so these factors can be used as markers of MVD in the BM [57,74,77,79,82,83,84,85,86]. This evidence concerns the gene MMP9 and B-cell chronic lymphocytic leukemia.