CLL cells and tumor-associated stromal cells also produce and secrete FGF-2, TNF-α, CXCL-12, CXCL-2, NGAL, IGF-1, progranulin, and angiogenin [88,89,90,91,92,93,94,95] (Table 1). This evidence concerns the gene GRN and B-cell chronic lymphocytic leukemia.