Analysis of the prostate cancer exome revealed that the kinesin heavy chain gene KIF5A was mutated in some prostate cancers, and amplification of KIF18B was significantly higher in tumours with PTEN mutations, supporting the hypotheses that vesicular trafficking machinery mutations may be oncogenic and that oncogenic mutations may involve vesicular trafficking machinery (Figure 7B) [166,226]. Here, PTEN is linked to Familial prostate cancer.