The BRCA2 variant NM_000059.3:c.8331+1G>A was identified in a 52-year-old patient that was diagnosed with bilateral BC at the ages of 39, with lobular carcinoma in the right breast, and 47, with ductal carcinoma in the left breast; both were PR and ER positive and HER2 negative. Here, ESR1 is linked to breast lobular carcinoma.