TGFβ is a suppressive cytokine that promotes several changes in the TME that favor tumor growth and resist antitumor immune cell infiltration, such as increasing production of collagen and other ECM proteins in the TME, which leads to a dense ECM that impedes T cell infiltration and also by promoting an immunosuppressive phenotype in stromal cells [155]. Here, TGFB1 is linked to neoplasm.