Complementarily, by predicting target genes of the deregulated miRNAs let-7c, miR-21, miR-34a, miR-126, miR-18a, miR-145, miR-221, miR-106a, miR-222, miR-143, and miR-106a in high-malignancy PCa, we identified potential modulation of genes such as UHRF2, MDM4, MET, SOX11, ERG, MYO6, GMFB, BCR, FOXS1, KIT, DMTF1, SORCS1, CCND1, STAT3, SKP2, CREBRF, MALT1, TP53INP1, RB1, E2F1, and BCL2L11 (Bim). This evidence concerns the gene E2F1 and posterior cortical atrophy.