Using the GeoMx® gene set, we also analysed transcriptomic signatures known to be associated with PCa aggressiveness: expression of the androgen receptor (AR) and its enhancers (FOXA1, HOXB13), ERG-dependent aggressiveness signatures (classified as ERG-dependent aggressive (S1), ERG-independent aggressive (S3), and non-aggressive (S2) [9]), and eQTLs associated with recurrent copy number changes at loci 2q, 5q, 6q, 8p, 8q, 10q, 13q, 16q, 17p, and 18q (Supplementary Figure S2). This evidence concerns the gene ERG and posterior cortical atrophy.