HOXB13 and posterior cortical atrophy: Using the GeoMx® gene set, we also analysed transcriptomic signatures known to be associated with PCa aggressiveness: expression of the androgen receptor (AR) and its enhancers (FOXA1, HOXB13), ERG-dependent aggressiveness signatures (classified as ERG-dependent aggressive (S1), ERG-independent aggressive (S3), and non-aggressive (S2) [9]), and eQTLs associated with recurrent copy number changes at loci 2q, 5q, 6q, 8p, 8q, 10q, 13q, 16q, 17p, and 18q (Supplementary Figure S2).