INS and type 2 diabetes mellitus: The 12-month weight loss lifestyle intervention, which was based on energy-restricted MeDi and PA promotion, successfully reduced cardiovascular risk factors and adiposity and improved glycemic control, insulin sensitivity, and dyslipidemia in participants with or at risk for T2DM, according to the PREDIMED-Plus trial, which involved more than 600 overweight/obese patients with metabolic syndrome [57].