RA increased the expression of NRF2 in the cord homogenates of animals with DM compared to animals with DM without treatment (p < 0.05) and induced HIF1 alfa and activation of NFkB compared to animals with DM and treated with Ro (p < 0.01 and p < 0.05) (Figure 8). The gene discussed is NFE2L2; the disease is diabetes mellitus.