CASP1 and early-onset autosomal dominant Alzheimer disease: Further studies have also demonstrated the efficacy of exogenous βHB in reducing plaque formation, microgliosis, and the formation of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) speck, as well as caspase-1 activation in the 5XFAD mouse model of Alzheimer’s disease (AD).