MLXIPL and obesity due to melanocortin 4 receptor deficiency: For example, in murine models, the gut microbial metabolite 2-oleoyl glycerol (2-OG), which is elevated after high-fat-diet-induced obesity, has been shown to increase de novo lipogenesis through up-regulation of SREBP1c and carbohydrate-response-element-binding protein (ChREBP), another transcription factor that enhances lipogenic enzymes such as FAS and ACC (Figure 2) [86].