Further, a six-month study on male C57BL/6 mice reported extensive macro- and microvesicular hepatic steatosis; pericellular fibrosis; hepatic stellate cell activation; infiltration of CD68+ macrophages; and increased pro-inflammatory proteins such NF-κβ (p65), IL-6, and TNF-α. Here, NFKB1 is linked to fatty liver disease.