Furthermore, the interaction between epigenetic factors and transcription factors including DNA hypermethylation with KLF4, as well as the interactions between DNA demethylation enzyme TET2 and RUNX1; DNMT3b and RUNX2; SETD7 and NF-κB; EZH2 and KLF2, KLF4, and STAT1; long noncoding RNA CDKN2BAS1 and EZH2 and CTCF; G9a and ATF7; HDACs and KLF2 and NRF2; and SIRT1 and NF-κB contribute to atherosclerosis [67]. This evidence concerns the gene KLF4 and atherosclerosis.