The regulation process also involved the regulation of immune, endocrine, and nervous systems, including inflammatory bowel disease, the intestinal immune network producing IgA, differentiation of Th1 and Th2 cells, the IL-17 signal transduction pathway, Th17 cell differentiation (immune disease), the AGE-RAGE signal transduction pathway in diabetes complications, etc. The regulation of pathways related to neuroimmune regulation in the body gradually increased with the deepening of heat stress. The gene discussed is RENBP; the disease is diabetes mellitus.