The signaling pathways mainly involved included the cancer pathway, serotonin synaptic pathway, cancer transcription disorder pathway, proteoglycan pathway in cancer, chemical carcinogenesis receptor activation pathway, EGFR tyrosine kinase inhibitor resistance pathway, PI3K Akt signal pathway, ovarian steroidogenesis pathway, VEGF signal pathway, lipid and atherosclerosis, etc. This evidence concerns the gene EGFR and cancer.