REN and hypertensive disorder: While the causes of spontaneous hypertension are multifactorial [17,18]—encompassing genetics, the sympathetic nervous system, and the renin–angiotensin system—the primary cause of L-NAME-induced hypertension is a reduction in NO production, which indirectly leads to overactivation of vasoconstrictor mechanisms, such as the renin–angiotensin system and increased oxidative stress [19].