PCSK9 and familial hyperaldosteronism: Differences in HDL composition and function have also been reported between FH, with PCSK9 gain-of-function FH patients exhibiting reduced anti-inflammatory, antioxidant, anti-thrombotic, and antiapoptotic activity, as well as differences in proteomic, lipidomic, and glycomic composition compared to healthy controls and LDLR variant FH [203].