BIK and colorectal cancer: In an animal model study, Jacouton et al. [164] showed that L. casei strain BL23 prevents the development of colorectal cancer, as it has immunomodulatory properties (reduces anti-inflammatory interleukin-IL-22) and has antiproliferative effect by regulating caspases (7 and 9) and the pro-apoptotic protein Bik.