At the onset of metabolism-associated fatty liver disease, LPS is produced in large quantities, hepatic macrophages are polarized toward the M1 type, and NLRP3 inflammatory vesicles are activated, which promotes the transcription and protein synthesis of inflammatory vesicle–associated components, ASC, Caspase-1, and Caspase-11. The gene discussed is NLRP3; the disease is fatty liver disease.