GLS2 expression has been reported to downregulate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signalling pathway in HCC [58] and GBM [36] cell lines, which has been related to a tumour suppressor function for GLS2 [37,59,60]. Here, AKT1 is linked to hepatocellular carcinoma.