In recent years, reports have shown that GLS2 may be carrying out some activities that may not be related to its catalytic activity, being considered as potential secondary functions likely related to its protein interaction domains, as it was found to physically associate with Dicer in HCC cells to mediate the stabilization and further maturation of miR-34a, resulting in oncogenic Snail repression and an anti-metastatic effect [38]. Here, DICER1 is linked to hepatocellular carcinoma.