More interestingly, in spontaneously hypertensive rats (SHRs)—a model of hypertension generated by selective breeding of rats for blood pressure—AgtR1a expression in the PVN increased with Na-K-Cl cotranspotor1 and was accompanied by decreased binding of DNMT1 and DNMT3a to AgtR1a. This evidence concerns the gene AGTR1 and hypertensive disorder.