STAT3 and irritable bowel syndrome: Our research identified several miRNAs implicated in the modulation of oxidative stress in IBD such as MiR-124, which suppresses apoptosis and induces ROS production, activating the STAT3 signaling pathway [92]; by contrast, miR-93a is a ROS modulator regulating NOX4 [175], but also miR-222-3p seems to be a crucial regulator of oxidative stress [46].