According to Niehl et al., CDC48-mediated translocation of MP from the ER-associated inclusions (that contain viral factories) at the late stage of infection could be a means by which the virus targets excessive amounts of MP for degradation to the ubiquitin–proteasome system (UPS) and/or “switches” from active intercellular spread to replication and virion production [40,128]. The gene discussed is PPP1CB; the disease is infection.