PPARGC1A and neuroblastoma: Garlic-derived diallyl disulfide has been demonstrated to increase peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression in a ROS-dependent manner, inducing mitochondrial biogenesis at an early stage of treatment that precedes cell cycle arrest and apoptosis in the human neuroblastoma (SH-SY5Y) cell line [22].