TNF and cervical squamous intraepithelial neoplasia: However, administration of STS to PAG-treated CIN rats markedly reduced the levels of plasma IL-6 and TNF-α in comparison with rats in CIN + PAG group (Figure 4B,C; p < 0.05) without significantly altering plasma IL-1β level compared to CIN + PAG rats (Figure 4A; p > 0.05).