Just like mice, obese humans also show increases in plasma LEAP2 and the LEAP2/acyl-ghrelin molar ratio; therefore, LEAP2 also positively correlates with some metabolic parameters connected to obesity such as the BMI, HOMA-IR, VAT volume, and serum triglycerides [56]. This evidence concerns the gene LEAP2 and obesity due to melanocortin 4 receptor deficiency.