Four weeks of aerobic exercise (60 min/day, 4 weeks) improved mitochondrial biogenesis and myocardial fibrosis by activating the Sirt1/PGC-1 α/PI3K/Akt signaling pathway and alleviated myocardial fibrosis in infarcted mice [105]. This evidence concerns the gene SIRT1 and Myocardial fibrosis.