TGFB1 and Myocardial fibrosis: A recent study demonstrated that exercise can effectively stimulate endothelial progenitor cells to secrete and release exosomes, upregulate miR-126 expression, and further target TGF-β, which may serve as a potential modality to ameliorate myocardial fibrosis by decreasing cardiomyocyte apoptosis and inhibiting cardiac fibroblast transdifferentiation [97].