LOXL2 and Myocardial fibrosis: Additionally, Hong et al. found that aerobic exercise (60 min/day, five times/week for 12 weeks) ameliorated myocardial fibrosis in aged hypertensive rats by inhibiting the lysyl oxidase-like 2 (LOXL-2)/TGF-β signaling pathway, as well as the expression of AT1R and FGF23 [121].