Research has reported that multiple miRNAs play important roles in myocardial fibrosis; intermittent aerobic exercise (60 min/day, five times/week for 8 weeks) can inhibit the TGF-β pathway by upregulating the expression of miR-29a and miR-101a, and ultimately reduce fibrosis and scar formation in the cardiac tissue of MI rats [101]. The gene discussed is TGFB1; the disease is myocardial infarction.