PRKAA1 and Myocardial fibrosis: Furthermore, swimming exercise (60 min/day, 8 weeks) was shown to protect the myocardium from hypertensive injury by alleviating myocardial fibrosis in hypertensive rats through the activation of the AMP-activated protein kinase α1 (AMPKα1)/Sirt1/peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) pathway [122].