Incremental loading exercise (15–60 min/day, five times/week for 6 weeks) has been shown to ameliorate renal fibrosis in aged mice by reducing extracellular matrix accumulation and delaying epithelial–mesenchymal transition through the modulation of the TGF-β1/TAK1/MKK3/p38MAPK signaling pathway and enhanced autophagy activation [87]. The gene discussed is TGFB1; the disease is renal fibrosis.