Wang et al. demonstrated that 15 weeks of aerobic exercise (60 min/day, 15 weeks) upregulates PGC-1 α and Akt expression in the heart of db/db mice, improving mitochondrial biogenesis and reducing cardiomyocyte apoptosis, thereby alleviating myocardial fibrosis [95]. Here, AKT1 is linked to Myocardial fibrosis.