One study indicated that aerobic exercise (45 min/day, five times/week for 4 weeks) induced an upregulation of endogenous H2S [50] and decreased activity in the TGF-β1/Smad and low-density lipoprotein receptor-related protein (LRP-6)/β-catenin signaling pathways, inhibiting EMT and thereby attenuating BLM-induced lung fibrosis [50]. Here, TGFB1 is linked to pulmonary fibrosis.