Subsequently, in two myopia models of guinea pigs (FD and negative lens induction), scleral HIF-1α level was found to be increased in the myopic sclera and affected scleral ECM remodeling; in vitro experiments have also demonstrated that hypoxia induces myofibroblast transdifferentiation of human scleral fibroblasts [11]. Here, HIF1A is linked to myopia.