In addition, gene set enrichment analysis (GSEA) of new genome-wide association study (GWAS) data of 593 patients with high myopia (diopter ≤ −6 diopter [D]) found that the HIF-1α signaling pathway was significantly enriched in patients with high myopia (diopter ≤ −10D) [13]. This evidence concerns the gene HIF1A and myopia.