Unlike the literature data reporting DNA hypermethylation as responsible for EGFL7/miR-126 downregulation in various tumors [23,24,25,26,27,28,29], we found the chromosomal region spanning the EGFL7/miR-126 gene to be hypomethylated in BC (Supplementary Figure S1a). The gene discussed is EGFL7; the disease is breast cancer.