Indeed, several genes—such as BMYB, FOXM1, polo-like kinase 1 (PLK1), Aurora kinase A (AURKA), and CCNB1—regulated and suppressed by the DREAM complex are overexpressed in various cancers and are associated with a poor cancer prognosis [79,80,81,82,83,84,85,86]. The gene discussed is PLK1; the disease is cancer.