TIMP1 and polycystic ovary syndrome: More recently, Ranjbaran, Farimani, Tavilani, Ghorbani, Karimi, Poormonsefi, and Khodadadi [22] reported no difference in the serum levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 but reported that the gelatinase activity of MMP-9 as well as the MMP-9/TIMP-1 ratio were significantly higher in women with PCOS.