An imbalance between MMPs and TIMPs, with lower concentrations of TIMP-2 and increases in MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios, has been reported in PCOS [27]; however, there remains controversy as to whether MMP-2 and/or MMP-9, for example, are elevated [23,24,28], unchanged [27,29], or reduced [30] in PCOS, where they have been shown to correlate with BMI but with their significance being lost when BMI was accounted for [31]. The gene discussed is TIMP2; the disease is polycystic ovary syndrome.