In a larger PCOS cohort (n = 80), while no differences in MMP-2, MMP-9, or TIMP-1 levels were observed, TIMP-2 levels were decreased and MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios were increased in the subjects with PCOS compared to the controls [27]. This evidence concerns the gene MMP2 and polycystic ovary syndrome.