Whilst MMP-17 did not differ between the subjects with PCOS and controls, the MMP-17/TIMP-1 was decreased in the subjects with PCOS, whilst MMP-17/TIMP-2 was increased, suggesting that there is differential control of MMP-17 depending on the binding of its inhibitors, but it is not clear whether the binding of the different TIMPs to MMP-17 may alter its function. This evidence concerns the gene TIMP1 and polycystic ovary syndrome.