INS and polycystic ovary syndrome: In a cohort of women classified as overweight with PCOS (n = 20), Liu, Guan, and Zheng [24] observed elevated serum levels of MMP-2 and decreased levels of IGFBP-1 compared to the age- and BMI-matched controls, with IGFBP-1 negatively correlating with MMP-2 and insulin levels and with BMI in subjects with PCOS.