MMP-2, MMP-14, TIMP-2, IGFBP-1, and IGF-1 were decreased in the subjects with PCOS compared to the controls (p < 0.005, p < 0.04, p < 0.048, p < 0.0001, and p < 0.0001, respectively). This evidence concerns the gene TIMP2 and polycystic ovary syndrome.