The MMP-9/TIMP-1, MMP-9/TIMP-2, and MMP-9/TIMP-3 ratios were all higher in the subjects with PCOS (p < 0.01), as were the MMP-17/TIMP-1 and MMP-17/TIMP-2 ratios (p = 0.01). The gene discussed is TIMP3; the disease is polycystic ovary syndrome.