The analysis of 12,427 consecutive RP specimens revealed that a heterozygous deletion of chromosome 13q—observed in 21% of cases—which includes the RB1 gene, was associated with adverse pathological features including high Gleason grade (p < 0.0001), advanced tumor stage (p < 0.0001), high preoperative PSA levels (p = 0.0125), and early biochemical recurrence (p < 0.0001). This evidence concerns the gene RB1 and neoplasm.