UGCG and neoplasm: In the present study, we have explored the role of GCS-inhibition with Genz-123346 together with the cationic amphiphilic drug aripiprazole in combination therapy with the multi-tyrosine kinase inhibitor sorafenib and the chemotherapeutic drug doxorubicin on the growth of hepatocellular cancer cells in monolayer and tumor spheroid culture.