In the present study, we have explored the role of GCS-inhibition with Genz-123346 together with the cationic amphiphilic drug aripiprazole in combination therapy with the multi-tyrosine kinase inhibitor sorafenib and the chemotherapeutic drug doxorubicin on the growth of hepatocellular cancer cells in monolayer and tumor spheroid culture. This evidence concerns the gene UGCG and hepatocellular carcinoma.