Due to the anti-amyloid properties of curcumin [32], and to further study the effect of curcumin on APP and amyloid peptides, pure curcumin as well as V-Cur were also evaluated In silico for their binding affinity with APP, Aβ, and Aβ fibrils, to further assess the potential to employ these two compounds in AD management. Here, APP is linked to Alzheimer disease.