Similarly, considering the intersection of reproducible proteins associated with CSF AD biomarkers and MMSE score (Figure 5b), the most enriched mechanism was the Activation of BAD and translocation to mitochondria (enrichment ratio = 130.793, FDR = 5.86 × 10−12), as more overlapping genes were identified in the filtered analysis than in the complete set of SomaScan proteins. Here, BAD is linked to Alzheimer disease.