Pathogenic variants in KCNQ2 are notoriously associated with neonatal epilepsies, which can range from a milder phenotype of self-limited neonatal epilepsy (SeLNE) or self-limited familial neonatal–infantile epilepsy (SeLFNIE) to the severe phenotype of KCNQ2–developmental epileptic encephalopathy (DEE) [4]. Here, KCNQ2 is linked to developmental and epileptic encephalopathy.