In addition to the three miRNAs identified in our study, recent research has expanded our understanding of miRNAs in osteoarthritis (OA), highlighting their significant involvement in key OA-associated signaling pathways, including MMP13 [11], STAT3 [12], SMAD2/3 [13], NOTCH3/Notch [14], and NF-κB [15]. The gene discussed is SMAD2; the disease is osteoarthritis.