TRAF6 and osteoarthritis: Meanwhile, Rasheed et al. found that miR-125b-5p inhibits inflammation by regulating the TRAF6/MAPKs/NF-κB pathway [34], and Ge et al. reported its elevated levels in severe osteoarthritis synovial cells, inversely correlated with SYVN1 expression, which it downregulates to promote apoptosis, highlighting its therapeutic potential [35].