Granzyme A and granzyme B are elements of the perforin (granule exocytosis) pathway and in the context of the importance of the perforin pathway and FasL, which likely coordinate to execute the GVT effect [25], our results link STAT6-mediated gene transcription directly to cytolytic molecules involved in conferring anti-tumor immunity. The gene discussed is GZMA; the disease is neoplasm.