MET and obesity due to melanocortin 4 receptor deficiency: Furthermore, the bioinformatic approach reported that other biological pathways associated with metabolism and/or adipocyte browning could be modulated by miR-1: the hepatocyte growth factor receptor signalling pathway, which has been linked to obesity and insulin resistance protection [50]; the regulation of JUN kinase activity, whose inactivation enhances energy expenditure and counteracts metabolic dysregulation in obesity [47]; and VEGF-activated neuropilin signalling pathway.