Moreover, a recent study revealed that EGFL8 expression was significantly decreased in hepatocellular carcinoma tissues and cell lines, and its downregulation was linked to more aggressive disease features, including multiple nodules, vascular invasion, advanced TNM stage, lung metastasis, poor prognosis, and decreased cell apoptosis and migration via the activation of the Notch signaling pathway [23]. This evidence concerns the gene EGFL8 and hepatocellular carcinoma.