Twist1 promotes ovarian cancer metastasis by upregulating discoidin domain receptor 2 (DDR2), a receptor tyrosine kinase (RTK) that recognizes fibrillar collagen as a ligand and enhances mesothelial clearance, invasion, and migration through matrix remodeling and Snail1 stabilization [43]. The gene discussed is NTRK1; the disease is ovarian carcinoma.