rPol d 5 is an allergen biomarker for genuine vespid venom sensitization, most suitable in regions with a high prevalence of Polistes dominula exposure and allergy, such as warmer climates or Mediterranean regions, which helps to identify the PdV as the primary sensitizer in cases with double IgE sensitization against AmV and PdV wve-s. This evidence concerns the gene IGHE and allergic disease.