This may include, after detailed history taking, in vitro IgE immunoassays and basophil activation tests using molecular allergen biomarkers, usually subsequently to in vivo allergy tests and/or in vitro measurement of serum specific IgE (ssIgE) against whole-venom extracts (wve-s) [1,2,3,4,5]. The gene discussed is IGHE; the disease is allergic disease.