A recent study [89] also demonstrated high hemodynamic values of SBP and MAP in OVX sedentary mice and concluded that the depletion of E2 caused by ovariectomy enhanced angiotensin II-induced hypertension and associated pathophysiological changes, including impaired autonomic and renal function, increased water intake and urinary levels of vasopressin, renal hypertrophy, fibrosis, and ROS production. The gene discussed is AGT; the disease is Hypertension.