AGT and hypertensive disorder: A recent study [89] also demonstrated high hemodynamic values of SBP and MAP in OVX sedentary mice and concluded that the depletion of E2 caused by ovariectomy enhanced angiotensin II-induced hypertension and associated pathophysiological changes, including impaired autonomic and renal function, increased water intake and urinary levels of vasopressin, renal hypertrophy, fibrosis, and ROS production.