Although BAF180’s precise role as a tumor suppressor is not fully understood, studies have revealed that the pathogenic variant in the protein polybromo 1 (PBRM-1) gene is found in nearly 30% of RCC; about 23.2% of PBRM-1 genetic alterations occur in ccRCC, while a significant portion of the 61.4% is associated with various cancers. The gene discussed is PBRM1; the disease is neoplasm.