The HIF1A-HIF2A complex favors tumorigenesis by activating other growth factors, such as Platelet-Derived Growth Factor Beta (PDGFB), Transforming Growth Factor Alpha (TGFA), and Vascular Endothelial Growth Factor (VEGF), which drive the progression of ccRCC [60]. This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.