Progressive accumulation of NFTs occurs in the neocortex, hippocampus, brainstem, amygdala, and spinal cord [137].Pre-tangles, characterised by argyrophilic tangle-like inclusions observed in the hippocampus and cortex, are present in the lack of amyloid pathology [138].Tau aggregation initially appears in the hippocampus and cerebral cortex, followed by the presence of NFTs and hyperphosphorylated tau in the frontal cortex and hippocampus, relative to the age-related rise in tau pathology [136].Hyperphosphorylated tau in the hippocampus and cerebral cortex [135]. Here, MAPT is linked to amyloidosis.