These studies found that highly active metabolic cancer-associated fibroblasts in endometrial cancer are characterized by the expression of the gene encoding Solute Carrier Family 2; Facilitated Glucose Transporter Member 1 (SLC2A1), a membrane protein involved in glucose uptake; Beta-1,4-Galactosyltransferase 1 (B4GALT1); and GTP-binding protein GEM (GEM). Here, GEM is linked to cancer.