Both of these subtypes shared characteristics of myofibroblast cancer-associated fibroblasts (mCAFs) because of the high level of expression of the genes encoding extracellular matrix building, i.e., COL4A1; ECM remodeling proteins, i.e., MMP11; and contractile proteins, i.e., TPPP3 and MYL9. The gene discussed is COL4A1; the disease is cancer.