HIGD1B and cancer: In HGSOC, the major fibroblast subtypes were inflammatory cancer-associated fibroblasts (iCAFs), characterized by surface markers such as Cell Adhesion Molecule 3 (CADM3), Perilipin-2 (PLIN2), and Desmin (DES); myofibroblast CAFs (mCAFs), defined by markers including CD140b, Complement Decay-Accelerating Factor (CD55), Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3), and HIG1 Domain Family Member 1B (HIGD1B); and stromal fibroblasts, characterized by Thy-1 (CD90), 5′-nucleotidase (CD73), and Endoglin (CD105).