The latest subpopulation to be described are apCAFs, which in cervical cancer are not defined by classical activation markers, i.e., the FAP, in comparison to other CAF subtypes; on the other hand, they express genes encoding uroplakin 3B (UPK3B) and MHC II complexes, i.e., HLA class II Histocompatibility Antigen Gamma Chain (CD74), HLA-DQA1 or HLA-DRB2 or a secreted protein, ADAMDEC1 (ADAM-Like Decysin 1). Here, UPK3B is linked to cervical cancer.