The study performed by Ma et al. demonstrated the remarkable capacity of HUCMSC-EVs to mitigate muscle atrophy in age-related and dexamethasone-induced sarcopenia mice models via the miR-132-3p/FoxO3 axis, providing valuable insight into the utilization of HUCMSC-EVs for the treatment of sarcopenia [137]. Here, FOXO3 is linked to sarcopenia.