RYR2 and catecholaminergic polymorphic ventricular tachycardia: CVPT-linked mutations in the RyR2 channel result in impaired Ca2+ release in diastole, particularly under adrenergic stress, leading to delayed afterdepolarizations (DADs) of the plasma membrane, which might trigger CPVT when they reach the action potential threshold [9,10,15,16].