SPP1 and neoplasm: Importantly, GB-induced CMA in murine PCs has been shown to increase the secretion of molecules such as Osteopontin (OPN) [18], which supports tumor growth [20,21,22,23], while the inhibition of this CMA upregulation leads to the release of molecules with anti-tumor properties, such as Lumican [18,24,25,26,27,28,29].